A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) have now discovered in mice that cells in the so-called stem cell niche are responsible for this: Blood vessel cells of the niche produce a factor that stimulates blood stem cells and thus maintains their self-renewal capacity. During aging, production of this factor ceases and blood stem cells begin to age.
source https://phys.org/news/2021-01-blood-stem-cells-lifelong-potential.html
