It is still the case that data from animal studies is required in order to evaluate the safety of a substance for humans. However, the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM has teamed up with 39 partners from 13 countries on a range of projects, all of which have a common aim: to bring about a paradigm shift—away from animal experimentation and towards a deeper understanding of how chemical substances work.
source https://phys.org/news/2021-01-animal-experimentation-chemical-methods.html