New information about adjuvant therapy to prevent recurrence of breast cancer in women 50 years of age or younger, or premenopausal, emerged today from the landmark Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx. An analysis of a pre-specified secondary endpoint in this largest-ever breast cancer treatment trial found that an assessment of a woman's recurrence risk based on classic clinical features—tumor size and histologic grade, adds prognostic information that is complementary to the 21-gene Recurrence Score (RS) test. Integration of the RS with clinical risk may help identify more young women who may be spared chemotherapy than originally reported. It may also help identify young women who stand to benefit from more effective anti-estrogen therapy. The analysis was published today in the New England Journal of Medicine and presented at the 2019 meeting of the American Society of Clinical Oncology in Chicago.
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