The human immune system relies on a delicate balance of finely tuned cell types that keep germs and cancerous cells in check. In cancer and chronic infections this balance can be disrupted, resulting in immune system dysfunction or "exhaustion." An important protein called TOX, which varies in amount in different immune cell types, controls the identity of the cells that become exhausted, according to researchers in the Perelman School of Medicine at the University of Pennsylvania. With this knowledge, investigators now have a way to accurately identify immune cells that are exhausted in a tumor or site of an infection, which could allow clinicians to improve the effectiveness of patients' immune response to cancer treatments by reinvigorating exhausted T cells. This work is published this week in Nature.
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